The P42 is something that has been needed since day one. It can fit in almost every US freight route. Horse shoe curve(2 services) sand patch grade(2 services) New York to Trenton(every amtrak service except aclea). Boston to Providence (every amtrak service except aclea) it would also be useful for the lake shore limited service on Boston to Providence in edition to them you could add the P42 heritage fleet and sleeper cars.
And Cajon Pass with the SW Chief. Although, Cajon would be a layer. Still hoping for a Pacific Surfliner, Amtrak Cascades/Seattle Sounder, Stevens Pass, or BNSF/Metra Chicago Racetrack routes. The P42 would be perfect for those routes.
Couple friendly corrections, Crystal... Like Killer said, the P42's on the NEC are far from every service aside from the Acela. You see them a bit around Ivy City and 30th Street, but not on electrified Regionals or trains operating primarily between DC and Boston. Pretty much any train that's not an Acela is powered by an ACS-64. Occasionally you'll see P42's under the wire, but that's usually if the power's out, work/test trains, rescues, etc. The other Genesis-series locomotive you would see out of NYP are the P32 dual-mode variants, but those are designated for the Hudson Line and upstate New York trains. Lately they've been running some P42's and P42C cab car conversions to top-and-tail the Empire Trains for push-pull operations, but that's only supposed to be a temporary measure to avoid sending those trains to Sunnyside while the East River Tunnels are being refurbed. Boston - Providence would use a P42, but that's only two trains a day, 448/449, and only one in each direction. They also wouldn't use anything from the heritage fleet, just Viewliners and Amfleets. Although currently the Boston leg of the Lake Shore is suspended right now due to a washout near Albany. They were also testing Chargers on those two prior to the closure.