You should be more specific. Is the loco no longer there? Which service? What did you try? Which controls did you try to use? What are meter readings? Are the brakes released or not? You cannot expect anyone just to guess what may be wrong. You also should change the title to be more descriptive. In the title you should at least mention route and loco and what the issue is. This increases the chance other people read about your problem. You even may get help.
You already have a thread like this in the PlayStation forums , and the reason you cannot drive the 425 on HMA is because you are on PlayStation which does not have layers for HMA