I’ve loaded the first service 5N01 Depot Move twice and on both times the train derails after passing the first points no matter what I do.
I completed the very first service of 5N01 where you go from Shields Depot to Glasgow Central on Xbox Series X and had no derailments
I ran into this issue on PC, to avoid it you have to set the manual switches correctly before setting off and it shouldn't happen. I'm reasonably confident this should not happen in real life and is a bug but at least there's a reasonably simple workaround.