Wich train do you use? Does it crash at the same point or different points? What kind of system do you have? It's more likely that someone on the forum can help you if you give more information.
The electirc locmotive with carriages. First time was on foot then took over. 10:10am approx Second time was a service timetable. Both are the same place. 06:10am approx Everytime I reach Meißen Altstadt from Triebischtal I am about 1 train length and it crashes. Unreal engine leaves some notes in a dialog box and I send a report.
You could try changing some visual settings to a lower one. It's probably at the point the game unloads some files. If that doesn't work try sending a ticket to dovetail games, mayby it's a more complex problem.
Okay. When it crashed, did it say your train derailed? I just did the 10:15 service with the 146.2 and I got a derail after coming leaving Meissen station.
I have major problems with the Meissen branch as well... It crashes nearly every single time. In scenario as well as timetable modes, all through the day.
Just a hunch, verify the integrity of the game files, if playing through Steam. I was having a similar issue on SEHS with a constant CTD on approach to Gravesend, a verify solved the problem.