I always drive the trains in TS2019 using a saitek throttle quadrant, for this i use the TS2015 Raildriver Interface from the UKTrainsim forum. This allows joysticks to control the trains using the raildriver plugin etc. It was working fine in both 32 and 64 bit versions of TS, but lately the buttons have stopped responding only in the 64 bit version. The levers still work fine in both 64 and 32 bit versions, it's just the buttons that are keybinded to keyboard letters that have stopped working only in the 64 bit version of TS2019... they used to work fine. The same is happening with the AutoHotKeys script i use to re-map media keys on my keyboard, i have a mouse move and click macro set up on the 'media button close' key, that moves the mouse to where the close window 'X' s are and clicks them... so i dont have to use the actual mouse to close the pop ups that some scenario writers have put in at every stop to tell you that you arrived on time or late and to go to the next stop. I also have some much simpler key re-maps, 3 media buttons are just mapped to keyboard keys for the german trains PZB buttons, and 2 more keys for the vR trains open and close doors buttons. But all these have stopped working in trainsimulator 64bit, yet they work fine in 32bit, so i'm wondering if a recent update has blocked this?
