After dropping off the remaining cars in the yard and uncoupling as required, train would not move to next destination to complete service. Nothing tried would get it to go. I tried brake resets, throttle resets, all switches off and back on, complete shut down and restart of loco, double checked uncoupled from train, ensured other loco was not in braking mode, made sure brake com was on in both locos, left driver's seat and returned to driver's seat. Nothing would allow me to continue service. Had to return to give up and return to main menu. Not the first time I have experienced this in Cajon yard services, but I do not recall the last service it occurred in.