It’s possible to make an improvement of the Game ( maybe the Core, I’m not an Expert ) to have an automatic changes of the units ( Imperial or Metric ) depending on the route like TS2020?
Yes, it's possible. It would be easier to tie it to the traction rather than the route. The HUD is already capable of displaying different brake types (vac/air) so there's no reason it couldn't have metric/imperial speedometers depending on the equipment on the locomotive. As to why DTG haven't implemented it, I have no idea!