Purely speculating here but when released will the Class 465 replace some of the 375s in the St Pancras to Faversham timetable? It would be more realistic for the 465s to run between Gillingham and Gravesend. Haven’t downloaded any loco DLC before so not sure how it works.
It entirely depends on the rolling stock being added to the game. Some add their own timetable services and run them exclusively while others are able to also substitute into a service usually ran by another loco. I reckon the 465 will do the latter but we'll see when it gets it's announcement.