This should be a relatively simple creation as its mainly just tunnels. But the class 345 with the elizabeth line would be an AMAZING route and I would love to see it on TSW5, it would be a day 1 purchase for me and others. Ive said this to loads of people and 95% of them have said they would love to see it too. Look at the overground line, that was a good line and alot of people really enjoyed that.
I personally find the route unlikely as DTG have said underground routes present a challenge due to way light works. Plus a big chunk would just be repeating Great Western Express
Not to mention the core is all automated, no driver input required to my knowledge except maybe with the doors?
If we get a Greater Anglia route out of Liverpool Street it may be viable. Although we'd only get a small part of it.