My German route suggestions are not very detailed compared to my UK suggestions. But I can make it detailed as much as I can. I am suggesting the line from Köln Hbf to Duisburg which includes major stations on the way such as Dusseldorf Hbf and Dusseldorf Flughafen. Rolling stock: National Express RRX BR 462 Thalys PBKA DB BR 422 (VRR) Layers: Layers are really flexible for German routes due to the amount of content intermixed ranging from S-Bahn, Regionalbahn, Regional Express and ICE services. BR 401 and 403 (Requires Kassel - Wurzburg) BR 406 (Requires Köln - Aachen) DB BR 146 + Dostos (Requires Kassel - Wurzburg) BR 110 + N-Wagens (Requires Bahnstrecke Bremen - Oldenburg) BR 423 (New Journeys Expansion) BR 101 I don't know about freight running between the two destinations.
For German Freight you are looking at the endpoint of Rbf Köln Kalk Nord or Köln Gremberg to Duisburg Gbf which is actually the yard behind the Central Station provided you own Bahnstrecke Witten/Dortmund-Oberhausen/Duisburg which is actually the formal name for Hauptstrecke Rhein Ruhr. Freight locomotives you are looking at a DB Baureihe 193 Vectron DB Baureihe 189 Eurosprinter the second Freight locomotive has the capability to run automatic couplers heavy Freight C-Akv Kupplung