For example, when I move the Warning Horn to Low on the Class 166 (by using a combination of A and the Left Thumb Pad), my Reverser moves from Forward to Neutral and Reverse. This also happens with other functions such as the Throttle/Brake.
This has also been happening to me in Rapid Transit and NEC New York. It takes a certain amount of time to start glitching. And, when the glitch starts, I'm forced to use the controller shortcuts.
Are you moving the switches in the cab with the precision mode (clicking RS) or in the "normal" mode when that happens?
Is this bug happening if you use the precision mode aswell? Maybe you can give it a shot in that mode. Because when not in that mode, moving the left stick to left or right while you try to pushing it forward might could change the reverser.