Well I have a fun one. On PC timetable service 1Y06 in the London Commuter - Brighton Mainline, the train instantly derails after loading in and clicking Get Started. It hangs a second then the train drops on the tracks and bumps around.
My experience with a similar issue (1A34 service - London Victoria to Brighton) is that you have a chance at starting the service by retrying to start it a few times. Make sure to not touch the mouse/keyboard before the startup is finished and the visuals are sharp. I had the impression that looking around too soon played a part in triggering the derail issue.
Thanks, i tried some other timetables which also had the same issue. I verified my game files in Steam which solved the issue even though no files were actually missing!