This SWR line goes from Waterloo to Weymourth with class 450s’707s and 455s. This route is very good it could be in this game.
Have you actually done any research into this? The entire route is too long, would need to be a section of it. What era do you want? Many of us recall the halcyon days of the 4 REP units with the 4TC trailer units, detached at Bournemouth for push/pull working to/from Weymouth. Or the 5WES era, or whatever icky plastic stuff runs on the route these days. The western end could also include the Weymouth Quay line if set in a suitable time period.
As OldVern said, this route in it's entirety is far to long for tsw2 plus most of the trains that operate along the whole length of this route are class 444's.
The OP has a habit of periodically spamming the board with one liner suggestions for routes that are impossible to put in TSW.
Too long and it can be broken down as SWML London Southampton then Southampton Bournemouth Weymouth. 1988 Weymouth Bournemouth electrification 6-12 months after LIRR Hicksville Ronkonkoma December 28th, 1987, electrification completion.