Pretty much 400 miles exactly via the quick way. A bit optimistic considering most of their routes are only 40-50 miles long. Only Class 390s go the quick way via the Trent Valley once an hour. Also once an hour, a Class 390/221 goes via Birmingham heading for either Glasgow Central or Edinburgh Waverley which takes about 45 minutes longer because it turns off at Rugby to go via Birmingham and Wolverhampton and rejoins at Stafford. So if you want Class 221s as well going Scotland you will have to add another 50miles making your request a mere 450 miles long. xx30 = Glasgow fast via Trent Valley (always Class 390) xx43 = Glasgow or Edinburgh via Birmingham (could be Class 390 or Class 221). Destination alternates hourly. E.g. 1243 goes Edinburgh then 1343 goes Glasgow.
If you post one line suggestions for routes nobody will take them seriously. Not that anyone would take a 400 mile route suggestion for TSW seriously. You must have noticed the length of routes you are already playing.