After playing with LGV Mediterrane this week I ran into two issues. I did submit a support ticket but they referred me to this forum and closed the ticket. Firstly I did encounter the random derailment incident that Sam ran into on one of the preview streams. Mine happened in the Bad Things scenario headed southbound as I crested a hill under braking. I realize this bug is probably impossible to track down and I haven't managed to recreate it since. Secondly I found it impossible to achieve a gold medal on the depot departure timetable services. Not necessarily game breaking per se, but really ought to be updated so you can achieve gold in journey mode.
The no gold medals for depot runs is a known issue . What speed were you going at when you had the issue on the scenario ?
I don't have a precise number but it would have been somewhere between 230kph nd 200kph and under braking. It was a few kilometers north of Aix en Provence, I think at the hill just before the big viaduct at Ventabren