I just changed the graphics settings so that the game would run in windowed mode. I then shut the game down so that the new setting could take effect. The game started up normally, but then threw up the typical O.O.M excuse while it was trying to update the scenario database. I verified the game files with Steam and everything checked out. I then restarted the game with LogMate running and I got this: 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:48:45.303 - [Content] - Trace cEntity.cpp : 1256 = Missing blueprint set "Kuju\" 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:48:45.303 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml" 2021/05/19 11:48:45.303 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint " d Gizmo\Scenario Markers\Standard Scenario Marker.xml" 2021/05/19 11:48:45.303 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "ml" 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : Kuju, ilSimul 2021/05/19 11:48:45.303 - [Content] - 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : Kuju, ilSimul 2021/05/19 11:48:45.303 - [Content] - 2021/05/19 11:48:45.303 - [Content] - Trace cEntity.cpp : 1256 = Missing blueprint set "Kuju\ilSimul" 2021/05/19 11:48:45.303 - [Content] - 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 266 = Blueprint set not found : Kuju, ilSimul 2021/05/19 11:48:45.303 - [Content] - 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : Kuju, ilSimul 2021/05/19 11:48:45.303 - [Content] - 2021/05/19 11:48:45.303 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:48:45.303 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml" 2021/05/19 11:48:50.398 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "RSrker.xml" 2021/05/19 11:48:50.398 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "Editor\Gizmo\Scenario Markers\Tutorial Scenario Marker.xml" 2021/05/19 11:48:50.398 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: editor\gizmo\scenario markers\standard scenario marker.xml 2021/05/19 11:48:50.398 - [Content] - Trace cEntity.cpp : 1256 = Missing blueprint set "rail\" 2021/05/19 11:48:50.398 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: editor\gizmo\scenario markers\standard scenario marker.xml 2021/05/19 11:48:50.398 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "editor\gizmo\scenario markers\standard scenario marker.xml" 2021/05/19 11:49:00.624 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : Kuju, L 2021/05/19 11:49:00.624 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:49:00.624 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : Kuju, L 2021/05/19 11:49:00.624 - [Content] - Trace cEntity.cpp : 1256 = Missing blueprint set "Kuju\L" 2021/05/19 11:49:00.624 - [Content] - Trace cBlueprintLibrary.cpp : 266 = Blueprint set not found : Kuju, L 2021/05/19 11:49:00.624 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : Kuju, L 2021/05/19 11:49:00.624 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:49:00.624 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml" 2021/05/19 11:49:05.731 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : , RailSimulatorCore 2021/05/19 11:49:05.731 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:49:05.731 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : , RailSimulatorCore 2021/05/19 11:49:05.731 - [Content] - Trace cEntity.cpp : 1256 = Missing blueprint set " \RailSimulatorCore" 2021/05/19 11:49:05.731 - [Content] - Trace cBlueprintLibrary.cpp : 266 = Blueprint set not found : , RailSimulatorCore 2021/05/19 11:49:05.731 - [Content] - Trace cBlueprintLibrary.cpp : 417 = Blueprint set not found : , RailSimulatorCore 2021/05/19 11:49:05.731 - [Content] - Trace cBlueprintLibrary.cpp : 448 = Blueprint set not found for: Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml 2021/05/19 11:49:05.731 - [Content] - Trace cEntity.cpp : 1272 = Missing blueprint "Editor\Gizmo\Scenario Markers\Standard Scenario Marker.xml" This crash is occuring on both 32-bit and 64-bit modes.
If you are missing items then a File Verify might be the answer If you have not done it before then in the Steam Client > Library > Right Click on Train Simulator > Properties > Local Files Verify Integrity of Game Files and let it run - when it is finished do it again.
With most DLC you get some form of manual Some of them are poor and you might not find the answer but it is worth looking
The next option is to report it to DTGs Help Desk https://forums.dovetailgames.com/threads/reporting-a-technical-issue.31193/
Just followed the advice from Smokebox in this thread https://steamcommunity.com/app/24010/discussions/3/1771511442690400114/ (first reply) and everything seems to be working now.