Never had an issue. QDs are different on each run, and depending on what consists get chosen randomly by the game - so it's also depending on other stuff you have installed, that others may not have.
This thread is a blast from the past - thanks for the reminder as I have this route marked as unplayable. Fault One still exsists - Manchester to Huddersfield Platform Bay 2 signal stuck on red - any train physically cant get there. It would have to go through the Huddersfield station and into the tunnel and reverse back into P2 from memory. The only fix I could suggest would be to delete Huddersfield Bay 2 from Quickdrive destinations at Victoria. Fault Two still exsists with the Eastbound crash to desktop just before Slaithwaite for any train. Only fix I can suggest is pick up TSW and Northern Trans Penine route in a sale and drive the very nice which works properly their. (although apparently we arent allowed to mention TSW on this side of the forum ))
Huddersfield Bay Platform 2 isn't accessible to passenger services from the Manchester direction in reality, only from Barnsley. ECS shunts are no doubt possible.